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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCS1
All Species:
40
Human Site:
T393
Identified Species:
58.67
UniProt:
Q01581
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q01581
NP_001091742.1
520
57294
T393
L
K
V
T
Q
D
A
T
P
G
S
A
L
D
K
Chimpanzee
Pan troglodytes
XP_517780
610
66491
T483
L
K
V
T
Q
D
A
T
P
G
S
A
L
D
K
Rhesus Macaque
Macaca mulatta
XP_001090857
592
65050
T465
L
K
V
T
Q
D
A
T
P
G
S
A
L
D
K
Dog
Lupus familis
XP_536483
637
69021
T510
L
R
V
T
Q
D
A
T
P
G
S
A
L
D
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8JZK9
520
57550
T393
L
K
V
T
Q
D
A
T
P
G
S
A
L
D
K
Rat
Rattus norvegicus
P17425
520
57415
T393
L
K
V
T
Q
D
A
T
P
G
S
A
L
D
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506375
520
57160
T394
L
K
V
T
Q
D
A
T
P
G
S
S
L
D
K
Chicken
Gallus gallus
P23228
522
57541
T394
I
R
V
T
Q
D
A
T
P
G
S
A
L
D
K
Frog
Xenopus laevis
NP_001087380
520
57303
M394
L
R
V
S
Q
D
A
M
P
G
S
S
L
D
K
Zebra Danio
Brachydanio rerio
NP_957379
508
55918
T383
I
K
V
T
Q
D
A
T
P
G
S
A
L
D
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524711
465
51158
Y341
N
M
Y
T
P
S
V
Y
S
G
L
V
S
L
L
Honey Bee
Apis mellifera
XP_397202
453
50855
Y329
P
S
Q
V
G
N
M
Y
T
P
S
V
Y
S
G
Nematode Worm
Caenorhab. elegans
P54871
462
51397
L338
P
S
L
F
A
Q
L
L
A
Y
L
A
A
D
D
Sea Urchin
Strong. purpuratus
XP_801879
508
56054
S380
I
A
L
F
S
Y
G
S
G
M
A
S
S
L
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P54873
461
51076
A337
A
S
L
Y
A
A
F
A
S
L
I
H
K
K
H
Baker's Yeast
Sacchar. cerevisiae
P54839
491
54995
T367
A
Q
S
L
I
V
P
T
N
T
G
N
M
Y
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85
87.3
78.6
N.A.
94.6
94.8
N.A.
90.1
83.9
80
77.6
N.A.
58
54.6
38.4
63.2
Protein Similarity:
100
85
87.3
80.5
N.A.
97.5
97.6
N.A.
95.3
91
88.6
87.1
N.A.
69.6
68.6
54.8
75.3
P-Site Identity:
100
100
100
93.3
N.A.
100
100
N.A.
93.3
86.6
73.3
93.3
N.A.
13.3
6.6
13.3
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
93.3
100
N.A.
13.3
13.3
20
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
44
45.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
60.1
60.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
13
7
0
0
13
7
63
7
7
0
7
57
7
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
63
0
0
0
0
0
0
0
69
7
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
13
0
0
7
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
7
0
7
0
7
69
7
0
0
0
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
7
% H
% Ile:
19
0
0
0
7
0
0
0
0
0
7
0
0
0
0
% I
% Lys:
0
44
0
0
0
0
0
0
0
0
0
0
7
7
63
% K
% Leu:
50
0
19
7
0
0
7
7
0
7
13
0
63
13
7
% L
% Met:
0
7
0
0
0
0
7
7
0
7
0
0
7
0
0
% M
% Asn:
7
0
0
0
0
7
0
0
7
0
0
7
0
0
0
% N
% Pro:
13
0
0
0
7
0
7
0
63
7
0
0
0
0
0
% P
% Gln:
0
7
7
0
63
7
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
19
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
19
7
7
7
7
0
7
13
0
69
19
13
7
0
% S
% Thr:
0
0
0
63
0
0
0
63
7
7
0
0
0
0
7
% T
% Val:
0
0
63
7
0
7
7
0
0
0
0
13
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
7
0
7
0
13
0
7
0
0
7
7
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _